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个人信息

姓名:张国柱

学历:博士

职称:教授,博士生导师

E-mailguozhuzhang@mail.ccnu.edu.cn

 

教育与研究经历

姓名、性别、头衔、获奖等信息

19969-20007月,天津南开大学化学系 学士

20009-20036月,天津南开大学化学系 硕士

20067-20113月,美国内华达大学里诺分校和加州大学圣塔芭芭拉分校 博士

20037-20067月,上海药明康德新药开发有限公司 合成研究员

20114-201310 美国哈佛大学 博士后

201311-20202 中国科学院上海有机化学研究所 课题组长/研究员

20203月至今 77779193永利官网 教授/博士生导师

 

中国国家优秀自费留学生奖2009、美国加州大学圣塔芭芭拉院长奖学金2010、中科院上海有机所百人计划2013)、Thieme Chemistry Journal Award (2015)并从2014年起担任《中国化学快报》青年编委

 

研究领域与兴趣

1.廉价过渡金属催化卤代烷烃自由基不对称成键反应研究

2.廉价化学品包括卤代烷烃,1,3-丁二烯,小分子张力环在过渡金属催化下的高选择性成环反应构建潜在药物活性环状分子

 

承担项目与课题信息

1.国家自然科学基金面上项目,金属催化1,3-丁二烯的三组分自由基不对称加成反应,2018.01-2021.1264万,在研,主持

2.国家自然科学基金面上项目,光诱导铜催化卤代烷烃远程 碳氢键不对称官能团化,2021.01-2024.1263万,在研,主持


学术成果(代表性论文)

1. X.-L. Mo, H. Huang, G.-Z. Zhang *,  Tetrasubstituted Carbon Stereocenters via Copper-Catalyzed Asymmetric  Sonogashira Coupling Reactions with gem-dihaloketones and α-bromo-γ-lactams ACS Catal. 2022, DOI 10.1021/acscatal.2c01973

2. Guo, R.; Xiao, H.; Li, S.; Luo, Y.; Bai, J.; Zhang, M.; Guo, Y.; Qi, X.; Zhang, G.* Photoinduced Copper-Catalyzed Asymmetric C(sp3)−H Alkynylation of Cyclic Amines by Intramolecular 1,5-Hydrogen Atom Transfer.  Angew. Chem. Int. Ed. 2022, 61, DOI: 10.1002/anie.202208232

3. Li, J.; Peng, Y.; Chen, B.; Guo, R.; Ma, X.; Xue, X.-S.; Liu, Y.; Zhang, G.* Azetidine synthesis enabled by photo-induced copper catalysis via [3+1] radical cascade cyclization. The Innovation, 2022, 3, https://doi.org/10.1016/j.xinn.2022.100244

4. Cao, Z.; Li, J.; Zhang, G.* Photo-induced copper-catalyzed sequential 1,n-HAT enabling the formation of cyclobutanols. Nat. Commun. 2021, 6404

5. Z. Cao, J. Li, Y. Sun, H. Zhang, X. Mo, X. Cao, G.-Z. Zhang* Photo-induced copper catalyzed alkynylation and amination of remote unactivated C(sp3)–H bonds, Chem. Sci. 2021, 12, 4836-4840.

6. C. Li, B. Chen, X. Ma, X. Mo, G.-Z. Zhang * Photo-Promoted Copper-Catalyzed Enantioselective Alkylation of Azoles, Angew. Chem. Int. Ed. 2021 60 2130-2134.

7. X.-L. Mo, B. Chen, G.-Z. Zhang *, Copper-Catalyzed Enantioselective Sonogashira Type Couplings of Alkynes with α-Bromoamide Angew. Chem. Int. Ed. 2020, 59, 13998-14002.

8. G.-Y. Lei, H.-W. Zhang, B. Chen, M.-C. Xu, G.-Z. Zhang*, Copper-Catalyzed Enantioselective Arylalkynylation of Alkenes, Chem. Sci. 2020, 111023-1028.

9. Y. Xiong, G.-Z. Zhang*, Enantioselective 1,2-Difunctionalization of 1,3-Butadiene by Sequential Alkylation and Carbonyl Allylation, J. Am. Chem. Soc., 2018, 140, 2735-2738.

10. X.-X. Zheng, R. Guo, G.-Z. Zhang,* D.-Y. Zhang,* Rhodium(I)-Catalyzed Asymmetric [4+2] Cycloaddition Reactions of 2-Alkylenecyclobutanols with Cyclic Enones through C-C Bond Cleavage: Efficient Access to trans-Bicyclic Compounds, Chem. Sci., 2018, 9, 1873-1877.

11. R. Guo, G.-Z. Zhang*, Expedient Synthesis of 1,5-Diketones by Rhodium-Catalyzed Hydroacylation Enabled by CC Bond Cleavage, J. Am. Chem. Soc., 2017, 139, 12891-12894.

12. R. Guo, X.-X. Zheng, D.-Y. Zhang*, G.-Z. Zhang* Rhodium(I)-Catalyzed Stereoselective [4+2] Cycloaddition of Oxetanols with Alkynes through C(sp3)-C(sp3) Bond Cleavage, Chem. Sci., 2017, 8, 3002-3006.

13. C.-J. Yu, B. Chen, T. Zhou, Q.-S. Tian, G.-Z. Zhang*, Gold (I)-Catalyzed Tandem Transformation with Diynes: Rapid Access to Cyclopentenone-Fused, Linear Polycyclic Molecules; Angew. Chem. Int. Ed. 2015, 54, 10903-10907.

 

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